GCF has funded Dr Nuala Helsby and her team at the University of Auckland, a year’s part time salary for a clinical trial manager to support the following research. THYmine2 is an observational study to assess whether the thymine loading test can prospectively categorise patients who cannot tolerate 5-FU treatment (e.g. FOLFOX, CapeOx, FLOX). This treatment is commonly used in GI and breast cancer treatment. Reactions occur in approximately 10% of patients and can result in life threatening events. Despite extensive research it is still difficult to determine who is at risk of life-threatening toxicity related to 5-FU. This study aims to examine whether the ratio of thymine to its metabolite in urine can discriminate between patients who tolerate 5-FU and those who experience severe 5-FU related toxicity. If successful then it could be a simple and inexpensive way to identify susceptible patients before they start treatment and allow for dose adjustments or alternative treatment. This is partly funded by the David Levene Foundation.
First ‘Pancreatic Cancer Ambassador’ appointed. Nyree Smith was diagnosed with pancreatic cancer in October 2017. After two rounds of surgery and chemotherapy, she is now cancer free. A survivor she supports others going through a cancer journey.